Diablo 4 Poison Damage & Poison Resistance

D4 Poison Damage

Poison is both a type of Elemental Damage and a collective name of debuffs that deal damage over time. Some poison attacks have variable damage and duration. Poison is typically associated with the color green, and takes the form of toxins, venom, and acids. Necromancers represent the Poison spells as the essence of Blight.

Some examples of death types that Rogues can trigger:

  • Eviscerate – Spill the insides of a monster
  • Shadow – Shadow energy deteriorates the life from a monster's flesh.
  • Freeze/Shatter - Break frozen monsters into pieces
  • Poison – The monster’s skin melts off leaving a heap of muscle and bone
  • Flay – Flay the skin from an enemy, leaving the muscle structure intact

Poison Damage Bonus:

  • Increases your Poison damage dealt. This includes both direct Poison damage and Poisoning damage over time.
  • You have +{#} of this stat from items and Paragon.

Poison Critical Strike Damage Bonus:

  • Extra damage granted to your Poison damage that Critically Strikes.
  • Stacks with your normal Critical Strike Damage Bonus.

Poisoning Damage Bonus:

  • Increases your Poisoning damage dealt. This includes Poison damage over time, but not direct Poison damage.
  • You have +{#} of this stat from items and Paragon.

Bonus Damage vs Poisoned Enemies:

  • Increases damage dealt to enemies who are Poisoned.

Damage Reduction from Poisoned Enemies:

  • Reduces incoming damage taken from enemies that are Poisoned.
  • As this stat increases, additional bonuses become less effective.

Damage Reduction from Enemies Affected by Damage Over Time:

  • Reduces incoming damage taken from enemies that are affected by any Damage Over Time effect. This includes Bleeding, Burning, Poisoning, and Shadow Damage Over Time.
  • As this stat increases, additional bonuses become less effective.

Poison Resistance

  • Reduces incoming Poison damage by {#}. This applies to both direct Poison damage and Poisoning damage over time.
  • Makes up 50% of your initial damage reduction from Poison, with the remainder contributed by Armor.
  • As this stat increases, additional bonuses become less effective.

Intelligence

  • Increases Resistance to All Elements by {#}

Elixir of Poison Resistance

Name RequiresDescription
Weak Elixir of Poison Resistance Level 15 Increases Poison Resist by 15% and Experience by 5% for 30 minutes.
Elixir of Poison Resistance Level 45 Increases Poison Resist by 20% and Experience by 5% for 30 minutes.
Strong Elixir of Poison Resistance Level 60 Increases Poison Resist by 25% and Experience by 5% for 30 minutes.
Potent Elixir of Poison Resistance Level 75 Increases Poison Resist by 32% and Experience by 5% for 30 minutes.
Heady Elixir of Poison Resistance Level 90 Increases Poison Resist by 40% and Experience by 5% for 30 minutes.
Curative Elixir Level 35 Makes you Unstoppable for 1 second, increases resistance to poisons and other negative effects by 50%, and increases Experience by 5% for 30 minutes.

You may only have one Elixir active at a time.

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Emerald Gems

Name Description Requires
Crude Emerald
  • Jewelry: 11.5% Poison Resistance
Level 15
Chipped Emerald
  • Jewelry: 14.3% Poison Resistance
Level 20
Emerald
  • Jewelry: 17.1% Poison Resistance
Level 40
Flawless Emerald
  • Jewelry: 19.9% Poison Resistance
Level 50
Royal Emerald
  • Jewelry: 22.7% Poison Resistance
Level 60

Diamond Gems

Name Description Requires
Crude Diamond
  • Jewelry: 4% Resistance to All Elements
Level 15
Chipped Diamond
  • Jewelry: 5% Resistance to All Elements
Level 20
Diamond
  • Jewelry: 6% Resistance to All Elements
Level 40
Flawless Diamond
  • Jewelry: 7% Resistance to All Elements
Level 50
Royal Diamond
  • Jewelry: 8% Resistance to All Elements
Level 60

Related Incense

Name RequiresDescription
Soothing Spices Level 75
Use: Increases all resistances by 10% and armor by 150 for every nearby player. Lasts 20 minutes.

This is a type II incense. Only one Incense of a type may be active at a time.
Storm of The Wilds Level 55
Use: Increases Lightning, Cold and Poison Resistances by 12% for every nearby player. Lasts 20 minutes.

This is a type I incense. Only one Incense of a type may be active at a time.

Poison Skills

NameDescriptionTagsPower NameRewards
Toxic Claws

Critical Strikes with Werewolf Skills deal {7.5/15/22.5/30/37.5/45/52.5/60/67.5/75}% of their Base damage as Poisoning damage over 4 seconds.


skill_rankup_desc: Poisoning Damage {7.5/15/22.5/30/37.5/45/52.5/60/67.5/75}%

Tags: Critical Strikes, Werewolf, Poison, Damage, Shapeshifting

Druid Talent Shapeshifting T4 N3
  • e type: 2
  • max talent ranks: 3
  • power id: 290971
  • power mod hash: 0
  • reward name: Druid Talent Shapeshifting T4 N3
Brutal Poison Creeper

Your Critical Strike Chance is increased by +20% against enemies strangled by Poison Creeper.

Tags: Companion, Poison, Damage, Cooldown, Crowd Control

Druid VineCreeper
  • e type: 1
  • max talent ranks: 3
  • power id: 314601
  • power mod hash: 2130055435
  • reward name: Druid Mod VineCreeper 02
Ferocious Poison Creeper

Poison Creeper's active Poisoning duration is increased by 3 seconds.

Tags: Companion, Poison, Damage, Cooldown, Crowd Control

Druid VineCreeper
  • e type: 1
  • max talent ranks: 3
  • power id: 314601
  • power mod hash: 2614886744
  • reward name: Druid Mod VineCreeper 01
Savage Rabies

Rabies deals its total Poisoning damage in 4 seconds instead of 6.

Tags: Wrath, Shapeshifting, Werewolf, Poison, Damage, Cooldown

Druid Rabies
  • e type: 1
  • max talent ranks: 3
  • power id: 416337
  • power mod hash: 2300425734
  • reward name: Druid Mod Rabies 02
Poison Creeper

Cooldown: 20 seconds
Lucky Hit Chance: 28% (per use)
Passive: A poison creeper periodically emerges from the ground every 7 seconds and applies {36/39.6/43.2/46.8/50.4/54/57.6/61.2/64.8/68.4}% Poisoning damage over 6 seconds to an enemy in the area.

Active: Vines strangle all surrounding enemies, Immobilizing them for 2 seconds and Poisoning them for {90/99/108/117/126/135/144/153/162/171}% damage over 2 seconds.


skill_rankup_desc: Passive Damage {36/39.6/43.2/46.8/50.4/54/57.6/61.2/64.8/68.4}%
Active Damage {90/99/108/117/126/135/144/153/162/171}%

Tags: Companion, Poison, Damage, Cooldown, Crowd Control

Druid VineCreeper
  • e type: 0
  • max talent ranks: 5
  • power id: 314601
  • power mod hash: 0
  • reward name: Druid Unlock VineCreeper
Neurotoxin

Poisoned enemies are slowed by {8/16/24/32/40/48/56/64/72/80}%.


skill_rankup_desc: Slow Amount {8/16/24/32/40/48/56/64/72/80}%

Tags: Poison, Crowd Control

Druid Talent Shapeshifting T3 N1
  • e type: 2
  • max talent ranks: 3
  • power id: 346283
  • power mod hash: 0
  • reward name: Druid Talent Shapeshifting T3 N1
Natural Rabies

Rabies spreads 100% faster.

Tags: Wrath, Shapeshifting, Werewolf, Poison, Damage, Cooldown

Druid Rabies
  • e type: 1
  • max talent ranks: 3
  • power id: 416337
  • power mod hash: 342636159
  • reward name: Druid Mod Rabies 01
Rabies

Cooldown: 12 seconds
Lucky Hit Chance: 50% (per use)
Shapeshift into a Werewolf and perform an infectious bite on the target dealing {28/30.8/33.6/36.4/39.2/42/44.8/47.6/50.4/53.2}% damage, and applying an additional {52.8/58.2/63.6/69/74.4/79.2/84.6/90/95.4/100.8}% Poisoning damage over 6 seconds.

Infected enemies spread Rabies to other surrounding targets.


skill_rankup_desc: Initial Damage {28/30.8/33.6/36.4/39.2/42/44.8/47.6/50.4/53.2}%
Poisoning Damage {52.8/58.2/63.6/69/74.4/79.2/84.6/90/95.4/100.8}%

Tags: Wrath, Shapeshifting, Werewolf, Poison, Damage, Cooldown

Druid Rabies
  • e type: 0
  • max talent ranks: 5
  • power id: 416337
  • power mod hash: 0
  • reward name: Druid Unlock Rabies
Enhanced Poison Creeper

Poison Creeper's Immobilize duration is increased by 1 second.

Tags: Companion, Poison, Damage, Cooldown, Crowd Control

Druid VineCreeper
  • e type: 1
  • max talent ranks: 3
  • power id: 314601
  • power mod hash: 3513029958
  • reward name: Druid Mod VineCreeper 03
Enhanced Rabies

Rabies' Poisoning damage also increases over the lifetime of the disease, dealing x30% bonus damage at max duration.

Tags: Wrath, Shapeshifting, Werewolf, Poison, Damage, Cooldown

Druid Rabies
  • e type: 1
  • max talent ranks: 3
  • power id: 416337
  • power mod hash: 1908890927
  • reward name: Druid Mod Rabies 03
Envenom

Poisoned enemies take x{10/20/30/40/50/60/70/80/90/100}% additional Critical Strike Damage.


skill_rankup_desc: Critical Strike Damage x{10/20/30/40/50/60/70/80/90/100}%

Tags: Poison, Critical Strikes, Damage

Druid Talent 15
  • e type: 2
  • max talent ranks: 3
  • power id: 1304803
  • power mod hash: 0
  • reward name: Druid Talent 15
Poison Imbuement

Cooldown: 13 seconds
Lucky Hit Chance: 33% (per use)
Imbue your weapons with lethal poison. Your next 2 Imbueable Skills deal Poison damage and apply {100/110/120/130/140/150/160/170/180/190}% of their Base damage as additional Poisoning damage over 5 seconds.


skill_rankup_desc: Poisoning Damage {100/110/120/130/140/150/160/170/180/190}%

Tags: Imbuement, Damage, Poison, Cooldown, Imbueable

Rogue PoisonImbue
  • e type: 0
  • max talent ranks: 5
  • power id: 358508
  • power mod hash: 0
  • reward name: Rogue Unlock PoisonImbue
Poison Trap

Cooldown: 10 seconds
Lucky Hit Chance: 20% (per use)
Place a trap that arms after {#} seconds. It activates when an enemy moves within range, applying {345.6/378/414/446.4/482.4/514.8/550.8/586.8/619.2/655.2}% Poisoning damage over 9 seconds to enemies in the area.

You can have 4 armed traps out at once.


skill_rankup_desc: Poisoning Damage {345.6/378/414/446.4/482.4/514.8/550.8/586.8/619.2/655.2}%

Tags: Subterfuge, Trap, Damage, Poison, Cooldown

Rogue PoisonTrap
  • e type: 0
  • max talent ranks: 5
  • power id: 416528
  • power mod hash: 0
  • reward name: Rogue Unlock PoisonTrap
Subverting Poison Trap

You deal x10% increased Poison damage to enemies standing inside your Poison Trap.

Tags: Subterfuge, Trap, Damage, Poison, Cooldown

Rogue PoisonTrap
  • e type: 1
  • max talent ranks: 3
  • power id: 416528
  • power mod hash: 1611127946
  • reward name: Rogue Mod PoisonTrap 01
Mixed Poison Imbuement

Lucky Hit: Poison Imbued Skills have up to a 30% chance to apply double the amount of Poisoning damage over time.

Tags: Imbuement, Damage, Poison, Cooldown, Imbueable

Rogue PoisonImbue
  • e type: 1
  • max talent ranks: 3
  • power id: 358508
  • power mod hash: 2056282291
  • reward name: Rogue Mod PoisonImbue 01
Deadly Venom

You deal x{3/6/9/12/15/18/21/24/27/30}% increased Poisoning damage.


skill_rankup_desc: Poisoning Damage x{3/6/9/12/15/18/21/24/27/30}%

Tags: Damage, Poison

Rogue Talent Cunning T2 N2
  • e type: 2
  • max talent ranks: 3
  • power id: 391675
  • power mod hash: 0
  • reward name: Rogue Talent Cunning T2 N2
Countering Poison Trap

Poison Trap has a 30% chance to reset your Imbuement Skill Cooldowns when activated.

Tags: Subterfuge, Trap, Damage, Poison, Cooldown

Rogue PoisonTrap
  • e type: 1
  • max talent ranks: 3
  • power id: 416528
  • power mod hash: 1670452712
  • reward name: Rogue Mod PoisonTrap 02
Blended Poison Imbuement

Critical Strikes with Poison Imbued Skills deal x75% increased Poisoning damage.

Tags: Imbuement, Damage, Poison, Cooldown, Imbueable

Rogue PoisonImbue
  • e type: 1
  • max talent ranks: 3
  • power id: 358508
  • power mod hash: 3923113625
  • reward name: Rogue Mod PoisonImbue 02
Debilitating Toxins

Poisoned enemies deal {5/10/15/20/25/30/35/40/45/50}% less damage.


skill_rankup_desc: Damage Reduction {5/10/15/20/25/30/35/40/45/50}%

Tags: Poison, Damage Reduction

Rogue Talent 05
  • e type: 2
  • max talent ranks: 3
  • power id: 1008675
  • power mod hash: 0
  • reward name: Rogue Talent 05
Alchemical Advantage

You gain +{1/2/3/4/5/6/7/8/9/10}% increased Attack Speed for each enemy you've Poisoned, up to +15%.


skill_rankup_desc: Attack Speed +{1/2/3/4/5/6/7/8/9/10}%

Tags: Poison, Attack Speed

Rogue Talent Discipline T4 N1
  • e type: 2
  • max talent ranks: 3
  • power id: 391667
  • power mod hash: 0
  • reward name: Rogue Talent Discipline T4 N1
Enhanced Poison Trap

Poison Trap Knocks Down enemies for 1.5 seconds when it activates.

Tags: Subterfuge, Trap, Damage, Poison, Cooldown

Rogue PoisonTrap
  • e type: 1
  • max talent ranks: 3
  • power id: 416528
  • power mod hash: 639386033
  • reward name: Rogue Mod PoisonTrap 03
Enhanced Poison Imbuement

Poison Imbuement's Poisoning Duration is increased by 1 second.

Tags: Imbuement, Damage, Poison, Cooldown, Imbueable

Rogue PoisonImbue
  • e type: 1
  • max talent ranks: 3
  • power id: 358508
  • power mod hash: 2300425734
  • reward name: Rogue Mod PoisonImbue 03

Notable users

There are two super unique monsters who have shot to fame by the strength of their Poison attacks alone. Poison is the main weapon of the Maiden of Anguish, Andariel and the Sand Maggot Queen, Coldworm the Burrower. The latter’s poison has been known to leave even the strongest characters at 1 health and almost always the death of the accompanying Hireling, But is only used when she dies and spills her green blood around her. Andariel uses her poison attacks much more often, and in a variety of ways. She has a poison bolt that travels along a straight line that does heavy damage per second if it strikes, or she could spread an arc-like wave of poison towards the player which does less damage than the previous attack but still is very dangerous. She can also inflict poison damage in her melee attacks. Both the above ladies do very high damage with their poison attacks, so it is highly advisable to have Antidote Potions in the Belt before fighting them.

For Battle.net only characters, there is another poison user, much more deadly than the aforementioned ladies of disease, the Demon Queen, Lilith. Lilith can be fought in the Pandemonium Event Battle.net only quest and she packs quite a mean punch with her other worldly poison attacks. They do hefty amounts of damage per second and stay on the character for a very long time. It is imperative that the player fights her with Antidotes on hand. It would also help if you keep some gold ready to resurrect your hireling after the fight.

Ghom is known for being the almost-exclusively Poison damage boss. Mummies and Accursed are known for leaving noxious vapors after death, dealing severe Poison damage to anything they touch.

In-game

In Diablo II, most players do not take Poison damage as seriously as Lightning. This may be due to its characteristic of doing damage over time, which can be balanced by using items that give Life Regeneration, and Healing Potions if Antidote Potions are not available. It should be noted that poison will never be the cause of death for the player’s hero, stopping at a Life total of 1. So, no character can be killed by poison damage alone. This can be used as an advantage by PvP players.

When you are poisoned, your Life orb turns green and you slowly lose Life.

Poison is quite commonplace in Act II, thanks to the Mummies and their greater cousins alone, although that’s not to say that the other acts don’t have their share of enemies that make use of this element.

Poison can instantly be cured with an Antidote Potion. Additionally, you can lower the amount of life you lose by increasing you character’s Poison Resistance. You can also reduce the duration of the poison with certain magic items and, if you are a Paladin, by using the Cleansing skill.

In Diablo III, poison may be an instant damage as well, but many Poison skills also apply damage over time effects, weaken the target, or create pools of poison and acid on the ground. Poison damage is only used by Lyndon, Witch Doctors and Necromancers, and hardly ever by other classes. Critical Hits from Poison damage may leave the target seething with toxic fumes, or just dissolve it to the bone. Only Witch Doctors and Necromancers roll Poison damage as Smart-Loot.

Andariel’s Visage, Stone of Jordan, Lidless Wall, Wormwood and Swamp Land Waders are the items with unconventional bonus to Poison skills damage. This actually leaves this damage type least capable of being boosted, even though it is, in fact, used by just two classes. Mara’s Kaleidoscope amulet will render the character completely immune to Poison damage (the attacks will actually heal the Nephalem).

D4 Guides & Tips