Diablo 4 Persist Target Lock

Options -> CONTROLS -> Controller -> Persist Target Lock.

Persist Target Lock

If enabled, target lock will remain active between encounters.

Demons seldom travel on their lonesome, often roaming Sanctuary in threatening packs. Among the chaos of a skirmish, it can be difficult to hit your intended target with an attack. Enabling Persist Target Lock will ensure your Skills and weapons stay focused on an enemy instead of whiffing.

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