A Sanctum run contains 4 floors, each containing 8 rooms. The 8th room of each floor always contains a Boss. Players can choose to engage in a room every time they encounter the portal to the Sanctum in an area or map, or defer up to 8 rooms (1 floor) to be run consecutively at a later time. Crashing during a Sanctum room will reset progress for that room and will resume the same area on your next map. Aureus and rewards are only locked in upon successful completion of a room. Each Sanctum run is independent between characters on the same account.
Header text | Kill all the Guards | Kill all the Guards (Skull Arena) |
Find the Exit | Find the Exit (Traps) | Defeat the Boss (Miniboss) |
---|---|---|---|---|---|
Floor 1: Sanctum Archives |
Chambers of Inscription | Templar Annals 1 central Skull, walls |
Abandoned Library | Holy Trials Mana Rune Squares |
Scriptorium |
Floor 2: Sanctum Vaults |
Derelict Caverns | Battlegrounds 1 central Skull, no walls |
Decrepit Cellar | Gauntlet | Reliquary |
Floor 3: Sanctum Cathedral |
Unholy Lair | Infernum 2 Skulls, dividing wall |
Halls of Worship | Crucible | Sanctum Bellum |
Floor 4: Sanctum Necropolis |
Lost Catacombs | Desecrated Crypt 1 Skull, 90 degree arc |
Undercroft | Entombment Rolling Boulders |
Mausoleum |
Note: most “Find the Exit” rooms have shortcuts that require movement skills.
Boss name | Boss room name | Based on: |
---|---|---|
Varakath, the Waxen | Sanctum Archives: Candlelit Chapel | Candlemass (POE2); also uses Blazing Salvo and a fire breath attack |
Braom, the First Experiment Uzar, the Second Experiment |
Sanctum Vaults: Experimentation Chamber | Slow moving statues that use slams. Braom can use a multidirectional Glacial Cascade, or Sunder while walking. Uzar can also create a homing Blood Orb leaving Enervating Ground. The bosses enrage when the other dies. |
Xenathar, Templar Reaper | Sanctum Cathedral: Hall of Mirrors | Vorana, Last to Fall; also uses wall-bouncing lasers, Divine Flare, and slow-moving Innocence projectile nova. |
Lycia, Unholy Heretic | Sanctum Necropolis: Sanctum Sanctorum | Phase 1: Attacks with sword swings and lunges, can summon Igneous Gargoyle adds and spawns a ring of DOT ground effect that drains Resolve. |
Lycia, Herald of the Scourge | The Beyond | Phase 2: Fires rotating lasers, an outward moving maze of sparks, and spinning staves. Does not damage resolve. |
Lycia, Herald of the Scourge in “The Beyond” will always drop a Sanctified Relic, as well as:
Complete any four of these encounters the specified number of times.