PoE 3.17 changes: The Maven’s Orb is now called the Orb of Dominance, and no longer drops from Maven.
Orb of Unmaking grants an atlas refund point. Each region has its own fixed tree, and only applies its bonuses to maps within that region. You earn passive points for each tree separately. However, Atlas respec points (which come from Orb of Unmaking) are not region-specific. Allocate your Atlas passive skills very carefully in order to obtain the maximum value, because refunding skillpoints requires an Orb of Unmaking that can be expensive. The price of Orb of unmaking is about 9 Chaos Orbs. Tip: If you are unsure what skills to allocate, close the interface and exit the Crucible. You can allocate your atlas skill points at anytime by opening your Atlas and clicking on the regional citadel button (the icon in the center of the citadel interface).
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How often you want to change your passives is up to the player and what they determine to be profitable.
An Orb of Regret grants a passive skill refund point in the passive skill tree.