The 3.20.1 update introduces the concept of Unique Relics. Every time you defeat the final form of the Sanctum Boss, she’ll drop a Unique Relic which challenges you to complete an entire run of The Forbidden Sanctum at area level 80+ under special rules. If you’re able to complete such a run, you’ll be rewarded in new and special ways. However, the Unique Relic will be destroyed regardless of the outcome of your run, so if you fail to complete it, you’ll forfeit your potential rewards.
We’ll go into more detail about Unique Relics and their rewards in the patch notes next week, but for the time being, here’s a teaser of one of the possible rewards you can earn:
Adds Magebane to a sanctified Relic. Stack size: 1/10. Right click this item then left click a non-corrupted sanctified relic to apply it.