Sisters to the Slaughter — Diablo 2 Resurrected

Diablo 2 Sisters to the Slaughter

Sisters to the Slaughter is a quest in Act 1. Mandatory, you must kill Andariel to advance to Act II.

Given: Given by Cain or by entering Catacombs 4.
Triggered By: Finishing the Malus Quest, or by reaching Catacombs level three
Location: Andariel’s Throne Room, Catacombs level four
Tips: Find Catacombs Level 4.
Description: It’s time to face the demon queen Andariel, who has corrupted the rogue sisterhood and defiled their ancient monastery. You must kill her before the Monastery becomes a permanent outpost of hell and the way east lost forever.
Rewards: You may travel with Warriv’s caravan to Lut Gholein and Act II.

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This is the only quest in Act I that you actually must complete. After dealing with The Smith, continue through the Barracks into the Jail. This area has three levels you’ll need to work through, which contain even more of the monsters you’re used to. The one notable addition is mana-draining Wraiths, which are just a tougher version of the Ghosts you fought in The Forgotten Tower. After you clear the Jail, you’ll be in The Inner Cloister. Make sure to pick up the Waypoint here and go and refill potions if you’re running low.

Then head into the Cathedral and make your way to the right-hand side of the map to head down into the Catacombs. This sprawling dungeon contains several new monsters. There are Arachs, The Banished, Afflicted, Ghouls, and Rat Men. On their own, none of these are too deadly, but having to learn how all of these different enemies work at once while also exploring an area that can lead to you feeling overwhelmed can be tough. Take your time and don’t be afraid to pop back to town for a breath. Make sure to pick up the Waypoint on the second level of the Catacombs so that you can speed up your corpse run if you happen to die.

Eventually, you’ll make your way to the fourth floor of the Catacombs. When you enter, you’ll be in an area where you’re safe. Take this time to drop a TP that you can use if you run into difficulties in the next room. Walk through the door and take some time to clear out all of the Dark Ones and their Shamans along with the Zombies. Make sure you don’t open the next door until they’re all dealt with or you’ll activate the Act boss, Andariel.

When everyone is dead, head through that door and face Andariel. Your first objective is to draw her closer to the door. You don’t want to activate all of the other enemies in the room with her if you can help it. Once she’s sauntered over to you, your best bet is to hit her with any fire attacks you have. She is very weak to fire and will go down quickly if you can hit with everything you have. If you don’t have access to fire-based skills, be ready with lots of potions because her attacks deal a lot of poison damage. Fortunately, this damage is slow-acting, so you can run through a portal back to town and be safe if you need to. Once she’s killed, grab your loot, head to town, and talk to Warriv to move onto Act II.


Use the blood lake in the second room to run in circles around if you can’t go toe to toe with Andariel, a common problem for ranged attacking characters early on. Poison antidote potions are very useful, as are items that cut poison duration. You should find some in Act One, save them to wear for Andariel.

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