Sanctified Relics can be corrupted by using an invocation, which adds a fixed Keystone as a corrupted implicit modifier.
Stack Size: 1/10.
Right click this item then left click a non-corrupted sanctified relic to apply it.
Lycia’s second form also drops a Unique Relic, which are one time use Relics that provide additional challenge and rewards to a Sanctum run in areas of level 80+. She can also drop invocations used to corrupt and add Keystones to Sanctified Relics.