|Mephisto’s Soulstone is a Quest Item for Hell’s Forge quests. It can be obtained at Durance of Hate by defeating Mephisto.
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When you approach the Hellforge the quest log should appear and you should encounter Hephasto the Armorer, a Unique Overlord boss similar to The Smith. Much like The Smith, Hephasto has a powerful melee attack and moves fast. It’s best to lure him away from the forge and kill him when he’s alone; it might be a tricky fight however. When he dies he will drop the Hellforge Hammer. Clear the area near the Forge and equip the hammer. When you click on the Hellforge, Mephisto’s Soulstone should disappear from your inventory and appear on the forge. Attack the forge; after two swings the Soulstone should shatter into several fragments and a storm of souls is unleashed.
After destroying the Soulstone, several high-quality gems will drop, including at least one Perfect gem, regardless of difficulty. A single rune will drop as well, with the rune quality increasing with difficulty: