Path of Exile 2 features a brand new campaign with six acts, 100 distinct environments, 600 monsters and 100 bosses.
Killing normal rarity monsters no longer grants flask charges.
Defeating optional story Bosses can grant items that grant permanent attributes and Spirit bonuses. These upgrades are character-specific. Larger bosses are more mobile because they can have multiple hitboxes, unlike the limit of 1 in POE1.