PoE Used when you become Poisoned Craft Recipe

Crafting Recipes Cost Unlock Locations Description Prefix /
Item Classes NPC
Used when you become Poisoned 5x Instilling Orb
5x Glassblower’s Bauble
Epilogue, Oriath Movement Speed and Flask Enchantments – Rank 3 Flask Helena

"Used when you become Poisoned" in Path of Exile offers a strategic and potentially life-saving Flask enchantment, adding a counterplay element against the insidious threat of poison damage. Let's delve into its benefits, considerations, and safe ways to utilize its potential:


This enchantment automatically triggers your chosen Flask the instant you are afflicted with the Poison ailment. This immediate response can mitigate the initial burst of poison damage and provide crucial tactical advantages.


  • Immediate Antidote: Flasks like Antivenin Flasks or Wise Oak Flasks can instantly remove or mitigate ongoing poison, preventing significant health loss and keeping you in the fight.
  • Offensive Opportunity: Certain Flasks like Quicksilver Flasks or Stibnite Flasks can boost movement speed or grant temporary immunity upon activation, enabling you to evade further poison sources or launch a decisive counterattack while still poisoned.
  • Increased Sustain: Builds reliant on enduring poison for specific mechanics can benefit from the controlled activation of Flask effects to manage their poison state strategically.


  • Charge Management: Ensure your build has reliable methods to refill Flask charges quickly, especially if facing multiple poison sources or relying on frequent activations.
  • Delay and Overlapping Effects: Keep in mind the slight activation delay of the Flask and ensure its effect overlaps sufficiently with the initial poison damage to effectively mitigate it.
  • Flask Choice: Carefully consider the Flask's effect you want to trigger – instant poison removal for defense, temporary immunity for aggressive strategies, or offensive boosts to capitalize on the poison state.

Safe Strategies:

  • Focus on Defense: Prioritize Flasks that directly remove or mitigate poison damage to ensure your survival against potent poison sources.
  • Combine with Recovery Mechanics: Use this enchantment alongside other skills or items that boost regeneration or offer damage over time mitigation for added defense.
  • Plan for Activation: Understand your enemy's attack patterns and anticipate when poison triggers are likely to occur, optimizing your Flask usage and avoiding unintended activations.

Remember: Always prioritize safety and survival when building around this enchantment. Experiment with different Flasks and strategies to find a balance that suits your build and encounter types. By using it carefully and thoughtfully, you can transform the threat of poison into a manageable challenge and unlock its potential for strategic counterplay in your Path of Exile journey!

Poison is an ailment that deals chaos damage over time to the affected target.

A hit of damage that has a chance to poison is capable of inflicting poison. Only physical and chaos damage are able to inflict poison.

Poison is a cumulatively stacking debuff. Each application—or ‘stack’—of poison remains present on the target dealing chaos damage over time until it runs its course. There is no limit to the number of poison stacks a target can have. A single “hit” can apply a maximum of one poison stack, therefore having more than 100% chance to poison is redundant.


The base damage per second dealt by a given application of poison equals 30% of the combined physical and chaos damage of the base damage dealt which applied that particular instance of poison.

As an ailment modifier, stats modifying spell damage and attack damage do not apply to poison, nor damage modifers that are only affected by the skill.

The following modifiers will directly affect the damage of poison:

  • Damage
  • Damage over Time
  • Damage over Time Multiplier
  • Chaos Damage over Time Multiplier
  • Chaos Damage
  • Poison Damage
  • Physical Damage (for poison caused by physical damage)

Minion, trap, mine or totem damage modifiers will also affect the damage of poison if it is applied by a minion, a trap, a mine, or a totem respectively.

Double damage from passives or items like Paradoxica does not affect poison damage. Double damage mechanic only modifies the hit damage, not the base damage – so it does not double ailment damage.

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Critical Strike Multiplier does not affect Poison damage, unless player has Perfect Agony keystone.

The damage multiplier for ailments from critical strikes exists independently from the critical strike multiplier used for hits.

A character’s base critical strike multiplier is 150%. This damage multiplier does not function as 50% more damage but as +50% to Damage over Time multiplier, which stacks additively with other sources of Damage over Time Multiplier for Ailments.

There currently exist no modifiers to this stat. However, the Perfect Agony keystone applies a percentage of modifiers to critical strike multiplier to the damage multiplier for ailments from critical strikes.


The default base duration of poison is 2 seconds. Viper Strike inflicts poison with a base duration of 4 seconds.

Increasing poison duration results in a longer-lasting poison that deals damage at the same rate [citation needed]. increased Poison Duration, increased Duration of Ailments on Enemies and Temporal Chains are means to increase the duration of poisons on enemies.

Removal, immunity, and unaffected by

  • A flask with the of Curing suffix removes poison on sip and grants immunity to it while active
  • Viper’s Scales grants immunity to poison
  • Boots crafted with Essence of Delirium grant immunity to poison
  • Maw of Conquest has the modifier “Unaffected by Poison” meaning poison can still be inflicted upon the character, but the character will not take damage from it

Dual Wielding

Local modifiers on a weapon (e.g. +#% to Damage Over Time Multiplier for Poison inflicted with this Weapon) only affect the portion of poison damage derived from the applicable weapon.

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