PoE Used when you become Poisoned Craft Recipe

Crafting Recipes Cost Unlock Locations Description Prefix /
Item Classes NPC
Used when you become Poisoned 5x Instilling Orb
5x Glassblower’s Bauble
Epilogue, Oriath Movement Speed and Flask Enchantments – Rank 3 Flask Helena

Poison is an ailment that deals chaos damage over time to the affected target.

A hit of damage that has a chance to poison is capable of inflicting poison. Only physical and chaos damage are able to inflict poison.

Poison is a cumulatively stacking debuff. Each application—or ‘stack’—of poison remains present on the target dealing chaos damage over time until it runs its course. There is no limit to the number of poison stacks a target can have. A single “hit” can apply a maximum of one poison stack, therefore having more than 100% chance to poison is redundant.


The base damage per second dealt by a given application of poison equals 30% of the combined physical and chaos damage of the base damage dealt which applied that particular instance of poison.

As an ailment modifier, stats modifying spell damage and attack damage do not apply to poison, nor damage modifers that are only affected by the skill.

The following modifiers will directly affect the damage of poison:

  • Damage
  • Damage over Time
  • Damage over Time Multiplier
  • Chaos Damage over Time Multiplier
  • Chaos Damage
  • Poison Damage
  • Physical Damage (for poison caused by physical damage)

Minion, trap, mine or totem damage modifiers will also affect the damage of poison if it is applied by a minion, a trap, a mine, or a totem respectively.

Double damage from passives or items like Paradoxica does not affect poison damage. Double damage mechanic only modifies the hit damage, not the base damage – so it does not double ailment damage.

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Critical Strike Multiplier does not affect Poison damage, unless player has Perfect Agony keystone.

The damage multiplier for ailments from critical strikes exists independently from the critical strike multiplier used for hits.

A character’s base critical strike multiplier is 150%. This damage multiplier does not function as 50% more damage but as +50% to Damage over Time multiplier, which stacks additively with other sources of Damage over Time Multiplier for Ailments.

There currently exist no modifiers to this stat. However, the Perfect Agony keystone applies a percentage of modifiers to critical strike multiplier to the damage multiplier for ailments from critical strikes.


The default base duration of poison is 2 seconds. Viper Strike inflicts poison with a base duration of 4 seconds.

Increasing poison duration results in a longer-lasting poison that deals damage at the same rate [citation needed]. increased Poison Duration, increased Duration of Ailments on Enemies and Temporal Chains are means to increase the duration of poisons on enemies.

Removal, immunity, and unaffected by

  • A flask with the of Curing suffix removes poison on sip and grants immunity to it while active
  • Viper’s Scales grants immunity to poison
  • Boots crafted with Essence of Delirium grant immunity to poison
  • Maw of Conquest has the modifier “Unaffected by Poison” meaning poison can still be inflicted upon the character, but the character will not take damage from it

Dual Wielding

Local modifiers on a weapon (e.g. +#% to Damage Over Time Multiplier for Poison inflicted with this Weapon) only affect the portion of poison damage derived from the applicable weapon.

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