Diablo 4 Uber Andariel

Uber Andariel is one of the most challenging and rewarding bosses in Diablo 4, typically found in high-level endgame content. She is an enhanced version of Andariel, the Maiden of Anguish, known for her deadly poison attacks and formidable combat abilities.

Key Features and Strategies for Defeating Uber Andariel:

Abilities and Attacks:

  1. Poison Attacks: Uber Andariel has powerful poison attacks that can deal significant damage over time. This includes poison projectiles and area-of-effect (AoE) poison clouds.
  2. Summoning Minions: She can summon minions to aid her in battle, making the fight more challenging.
  3. Melee and AoE Attacks: In addition to poison, she has strong melee attacks and AoE damage abilities.


  1. Poison Resistance: Equip gear with high poison resistance to mitigate her poison damage. Use potions or buffs that enhance poison resistance.
  2. Health Potions: Stock up on health potions and antidotes to counteract poison damage.
  3. Gear and Build: Optimize your gear and build for high damage output and survivability. Consider skills and talents that enhance your ability to resist poison and crowd control.


  1. Positioning: Keep moving to avoid her poison AoE attacks and to stay out of melee range. Use hit-and-run tactics if necessary.
  2. Focus on Minions: Quickly eliminate any minions she summons to avoid getting overwhelmed.
  3. Consistent Damage: Maintain consistent damage output while managing your health and avoiding her poison attacks.
  4. Team Coordination: If you’re playing in a group, coordinate with your team to manage aggro, heal, and maximize damage.


  • High-Quality Gear: Defeating Uber Andariel can yield high-quality gear, including legendary and set items.
  • Materials and Crafting Items: She may drop valuable crafting materials used for upgrading and enchanting gear.
  • Achievements and Titles: Completing the challenge of defeating Uber Andariel may unlock achievements or titles.

Farming Tips:

  1. Group Play: Consider teaming up with other players to tackle Uber Andariel more effectively.
  2. Efficient Builds: Use builds specifically designed for high damage output and poison resistance.
  3. Repeated Runs: Farming Uber Andariel repeatedly can help you gather a significant amount of high-quality loot and materials.

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Defeating Uber Andariel is a test of your character’s build, gear, and your strategic prowess. Preparing thoroughly and executing your tactics effectively will be key to overcoming this formidable challenge.

Guides & Tips