Each room contains several unique Sanctum Guards. All Guards must be killed before being able to complete the room.
| Guard type | Identifying features | Skills |
|---|---|---|
| Entombing Warden | Coldsnap Bow | Ice Snipe, Cold Rain of Arrows |
| Masked Combatant | Gray hood | Proximity Bomb, Smoke Mine, Mirror Image on Hit |
| Azure Assassin | Arcane Lightning Helmet | Decelerating Projectile into Lightning Vortex, Galvanic Arrow |
| Templar Marksman | Dragon Hunter Bow, Heritage Helmet | Dodge Roll, Flare Arrow, Blast Rain |
| Infernal Sentinel | Dawnbreaker | Slash, Fire Thrust, Projectile Cleave , Shield Charge |
| Obsidian Sentinel | Kongor’s Undying Rage | Consecrated Path, Summon Unholy Relic |
| Crimson Archmage | Witchhunter’s Judgment, skull head | Flameblast, Fireball, Fire Twister |
| Deathly Archmage | Skull head | Ice Spear Volley, Spike Wave, Ice Crash |
| Undying Archmage | Mystic Staff, skull head | Projectile Bolt, Vorana orbs, Storm Burst |
| Deadly Bladedancer | Crypt Sword | Sweep Cleave, Flicker Strike |
Each room other than the miniboss room contains several Guard unique monsters, as well as one of three tasks to complete the room:
| Room Goal | Defeat all the Guards | Defeat all the Guards (Skull Arena) |
Find the Exit | Find the Exit (Traps) |
Defeat the Boss (Miniboss) |
|---|---|---|---|---|---|
| Floor 1: Sanctum Archives |
Chambers of Inscription | Templar Annals 1 central Skull, walls |
Abandoned Library Ice Traps |
Holy Trials Mana Rune Squares |
Scriptorium Crimson Archbishop |
| Floor 2: Sanctum Vaults |
Derelict Caverns | Battlegrounds 1 central Skull, no walls |
Decrepit Cellar Ice Traps |
Gauntlet Rolling Exarch Boulders |
Reliquary Greater Wraith |
| Floor 3: Sanctum Cathedral |
Unholy Lair | Infernum 2 Skulls, dividing wall |
Halls of Worship Ice Traps |
Crucible Mana Rune Squares and Skull |
Sanctum Bellum Aureate Guardian |
| Floor 4: Sanctum Necropolis |
Lost Catacombs | Desecrated Crypt 1 Skull, 90 degree arc |
Undercroft Ice Traps and Skull |
Entombment Rolling Exarch Boulders or Mana Rune Squares + Lasers |
Mausoleum Colossal Lithomancer |
Note: most “Find the Exit” rooms have shortcuts that require movement skills.