Experimentation Chamber -- Path of Exile
A Sanctum run contains 4 floors, each containing 8 rooms. The 8th room of each floor always contains a Boss. Players can choose to engage in a room every time they encounter the portal to the Sanctum in an area or map, or defer up to 8 rooms (1 floor) to be run consecutively at a later time. Crashing during a Sanctum room will reset progress for that room and will resume the same area on your next map. Aureus and rewards are only locked in upon successful completion of a room. Each Sanctum run is independent between characters on the same account.
Experimentation Chamber Sanctum Room
| Name | Icon | Floor | Contains |
|---|---|---|---|
| Experimentation Chamber | Sanctum Vaults |
All room types other than boss rooms can become Afflicted. Afflicted rooms are indicated by a purple border and cause the character to gain an Affliction on entry.
Each room contains several Guard unique monsters, as well as one of three tasks to complete the room:
- Find the Exit (locate the exit door)
- Defeat all the Guards (defeat every unique Guard)
- Survive (avoid the traps)
- Defeat the Boss (minibosses based on map bosses)
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The Experimentation Chamber is a particularly intense and climactic room encountered in The Forbidden Sanctum, Path of Exile's end-game Sanctum mechanic. Prepare for a battle royale against powerful bosses, demanding quick thinking and strategic reflexes!
Layout:
- This room features a spacious arena with a central platform and raised walkways flanking its sides.
- Expect shattered equipment and ominous machinery, hinting at the grisly experiments conducted within.
Enemies:
- Uzar and Braom: The main attraction! These dual bosses boast unique abilities and relentless attacks, testing your combat prowess to the limit.
- Uzar: A hulking brute wielding dual axes, unleashing shockwaves and fiery slams.
- Braom: A nimble spellcaster conjuring chilling projectiles and summoning ghostly minions.
Challenges:
- Dual Threat: Managing both Uzar and Braom simultaneously requires constant repositioning and tactical awareness.
- Enraged Bosses: Upon dealing significant damage to one boss, the other enters an enraged state, gaining increased power and ferocity.
- Corrupted Platforms: Stepping on certain areas triggers bursts of electricity or corrosive ooze, adding an environmental hazard to the mix.
Tips for Conquering the Experimentation Chamber:
- Prioritize burst damage: Focus on taking down one boss quickly to avoid triggering the enraged state on the other.
- Utilize movement skills: Dodge attacks, reposition around the arena, and exploit openings created by the bosses' animations.
- Manage crowd control: Keep Braom's minions in check, as they can overwhelm you while focusing on the main bosses.
- Be mindful of the platforms: Avoid the electrified and corrosive zones to maintain health and mobility.
- Consider the Relics: Certain Relics can offer buffs against specific elements or grant temporary invulnerability, providing crucial advantages.
Rewards:
- Sanctum Chests: These chests hold valuable loot specific to the Sanctum, such as Offering Vessels with powerful boons.
- Currency Shards: You might encounter shards of high-tier currencies, like Exalted Orbs or Divine Orbs.
- Progression towards the final challenge: Clearing the Experimentation Chamber unlocks the path to the Sanctum's final boss, offering the ultimate test of your skills and resolve.
Overall, the Experimentation Chamber is a thrilling culmination of The Forbidden Sanctum's challenges. By employing masterful combat skills, tactical thinking, and precise movement, you can overcome these formidable bosses and claim the valuable rewards that await. Good luck, Exiles!
List of Sanctum Rooms
| Name | Icon | Floor | Contains |
|---|---|---|---|
| Abandoned Library | Sanctum Archives | ||
| Templar Annals | Sanctum Archives | ||
| Chambers of Inscription | Sanctum Archives | ||
| Holy Trials | Sanctum Archives | ||
| Scriptorium | Sanctum Archives | ||
| Candlelit Chapel | Sanctum Archives | ||
| Merchant |  | Sanctum Archives | Contains Merchant |
| Accursed Pact |  | Sanctum Archives | Contains Accursed Pact |
| Fountain |  | Sanctum Archives | Contains Fountain |
| Afflicted Fountain |  | Sanctum Archives | Contains Afflicted Fountain |
| Benevolent Fountain |  | Sanctum Archives | Contains Benevolent Fountain |
| Radiant Fountain |  | Sanctum Archives | Contains Radiant Fountain |
| Offer |  | Sanctum Archives | Offers Items on Completion |
| Major Treasure |  | Sanctum Archives | Contains Major Treasure Reward |
| Minor Treasure |  | Sanctum Archives | Contains Minor Treasure Reward |
| Candlelit Chapel |  | Sanctum Archives | Contains Varakath, the Waxen |
| Battleground | Sanctum Vaults | ||
| Decrepit Cellar | Sanctum Vaults | ||
| Derelict Caverns | Sanctum Vaults | ||
| Gauntlet | Sanctum Vaults | ||
| Reliquary | Sanctum Vaults | ||
| Experimentation Chamber | Sanctum Vaults | ||
| Merchant | | Sanctum Vaults | Contains Merchant |
| Accursed Pact | | Sanctum Vaults | Contains Accursed Pact |
| Fountain | | Sanctum Vaults | Contains Fountain |
| Afflicted Fountain | | Sanctum Vaults | Contains Afflicted Fountain |
| Benevolent Fountain | | Sanctum Vaults | Contains Benevolent Fountain |
| Radiant Fountain | | Sanctum Vaults | Contains Radiant Fountain |
| Offer | | Sanctum Vaults | Offers Items on Completion |
| Major Treasure | | Sanctum Vaults | Contains Major Treasure Reward |
| Minor Treasure | | Sanctum Vaults | Contains Minor Treasure Reward |
| Candlelit Chapel |  | Sanctum Vaults | Contains Braom and Uzar, the Experiments |
| Halls of Worship | Sanctum Cathedral | ||
| Unholy Lair | Sanctum Cathedral | ||
| Infernum | Sanctum Cathedral | ||
| Crucible | Sanctum Cathedral | ||
| Sanctum Bellum | Sanctum Cathedral | ||
| Hall of Mirrors | Sanctum Cathedral | ||
| Merchant | | Sanctum Cathedral | Contains Merchant |
| Accursed Pact | | Sanctum Cathedral | Contains Accursed Pact |
| Offer | | Sanctum Cathedral | Offers Items on Completion |
| Fountain | | Sanctum Cathedral | Contains Fountain |
| Afflicted Fountain | | Sanctum Cathedral | Contains Afflicted Fountain |
| Benevolent Fountain | | Sanctum Cathedral | Contains Benevolent Fountain |
| Radiant Fountain | | Sanctum Cathedral | Contains Radiant Fountain |
| Major Treasure | | Sanctum Cathedral | Contains Major Treasure Reward |
| Minor Treasure | | Sanctum Cathedral | Contains Minor Treasure Reward |
| Candlelit Chapel |  | Sanctum Cathedral | Contains Xenathar, Templar Reaper |
| Lost Catacombs | Sanctum Necropolis | ||
| Desecrated Crypts | Sanctum Necropolis | ||
| Undercroft | Sanctum Necropolis | ||
| Entombment | Sanctum Necropolis | ||
| Mausoleum | Sanctum Necropolis | ||
| Sanctum Sanctorum | Sanctum Necropolis | ||
| Fountain | | Sanctum Necropolis | Contains Fountain |
| Afflicted Fountain | | Sanctum Necropolis | Contains Afflicted Fountain |
| Benevolent Fountain | | Sanctum Necropolis | Contains Benevolent Fountain |
| Radiant Fountain | | Sanctum Necropolis | Contains Radiant Fountain |
| Merchant | | Sanctum Necropolis | Contains Merchant |
| Accursed Pact | | Sanctum Necropolis | Contains Accursed Pact |
| Offer | | Sanctum Necropolis | Offers Items on Completion |
| Major Treasure | | Sanctum Necropolis | Contains Major Treasure Reward |
| Minor Treasure | | Sanctum Necropolis | Contains Minor Treasure Reward |
| Candlelit Chapel |  | Sanctum Necropolis | Contains Lycia, Unholy Heretic |