Players may choose from 39 Survivors, some created specifically for the game and some licensed from other horror franchises. They are listed below in the order in which they were released.
| Survivor | Franchise | Description |
|---|---|---|
| Dwight Fairfield | Original characters | A nervous leader. |
| Meg Thomas | An energetic athlete. | |
| Claudette Morel | A studious botanist. | |
| Jake Park | A solitary survivalist. | |
| Nea Karlsson | An urban artist. | |
| Laurie Strode | Halloween | A determined babysitter. |
| Ace Visconti | Original character | A lucky gambler. |
| William "Bill" Overbeck | Left 4 Dead | An old soldier. |
| Feng Min | Original characters | A focused competitor. |
| David King | A rugged scrapper. | |
| Quentin Smith | A Nightmare on Elm Street | A resolute dreamwalker. |
| David Tapp | Saw | An obsessed detective. |
| Kate Denson | Original characters | A hopeful songbird. |
| Adam Francis | A resourceful teacher. | |
| Jeff Johansen | A quiet artist. | |
| Jane Romero | An influential celebrity. | |
| Ash Williams | Evil Dead | An alone wolf. [sic] |
| Nancy Wheeler | Stranger Things | An aspiring journalist. |
| Steve Harrington | A former jock. | |
| Yui Kimura | Original characters | A hardened street racer. |
| Zarina Kassir | A plucky documentarian | |
| Cheryl Mason | Silent Hill | A young veteran of terror. |
| Felix Richter | Original characters | A visionary architect. |
| Élodie Rakoto | An occult investigator. | |
| Yun-Jin Lee | A self-interested music producer. | |
| Jill Valentine | Resident Evil | A founder of STARS. |
| Leon S. Kennedy | A rookie police officer. | |
| Mikaela Reid | Original characters | A young mystic. |
| Jonah Vasquez | A mathematical mastermind. | |
| Yoichi Asakawa | Ring | A brilliant marine biologist. |
| Haddie Kaur | Original character | A brave podcaster. |
| Ada Wong | Resident Evil | A mysterious secret agent. |
| Rebecca Chambers | A gifted medic and squad member. | |
| Vittorio Toscano | Original characters | An endless wanderer. |
| Thalita Lyra | A skilled and competitive kite fighter. | |
| Renato Lyra | ||
| Gabriel Soma | A resourceful engineer. | |
| Nicolas Cage | Real life | A superstar. |
| Ellen Ripley | Alien | A warrant officer of the Nostromo. |
Additionally, nine Legendary skins have been added which turn their respective Survivor into alternate Survivor characters. They are listed below in the order in which they were released.
| Legendary Survivor | Franchise | Original Survivor |
|---|---|---|
| Lisa Garland | Silent Hill | Cheryl Mason |
| Cybil Bennett | ||
| James Sunderland | ||
| Maria | ||
| Jonathan Byers | Stranger Things | Steve Harrington |
| Chris Redfield | Resident Evil | Leon S. Kennedy |
| Carlos Oliveira | ||
| Claire Redfield | Jill Valentine | |
| Sheva Alomar |
While not Legendary skins, these outfits give original Survivors appearances reminiscent of licensed characters from other series. They are listed below in the order in which they were released.
| Outfit | Franchise | Original Survivor |
|---|---|---|
| Francis | Left 4 Dead | Jake Park |
| Zoey | Meg Thomas | |
| Ellis | Dwight Fairfield | |
| Rochelle | Claudette Morel | |
| Eren Yeager | Attack on Titan[c] | Dwight Fairfield |
| Mikasa Ackerman | Yui Kimura | |
| Levi Ackerman | Jake Park | |
| Annie Leonhart | Meg Thomas | |
| Armin Arlert | Felix Richter | |
| Historia Reiss | Kate Denson | |
| Hange Zoë | Zarina Kassir | |
| Kenny Ackerman | Ace Visconti | |
| BSAA Uniform | Resident Evil | Felix Richter |
| Jill Valentine Cosplay | Feng Min | |
| Princess Heart Cosplay | Silent Hill | Feng Min |
| Wonderful Alice | Alice in Wonderland | Kate Denson |
| Cheshire Life | Nea Karlsson | |
| Mad Hatter | Ace Visconti |